کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5131019 | 1490851 | 2017 | 13 صفحه PDF | دانلود رایگان |
- Characterization of γ-irradiation, batch effect and ageing on two multilayer polymer films.
- Powerful method to identify influential factors and interactions for experimental design multivariate response.
- Each factor and interaction could be interpreted as changes in polymers structures.
- The relevance of each effect could be evaluated.
To highlight the main factors involved in the degradation of polymers in multilayer films under γ-irradiation, the ANOVA Common Dimensions (AComDim, Analysis of Variance in Common Dimensions) method is applied on spectra recorded with ATR-FTIR (Attenuated Total Reflection-Fourier Transform Infrared). The present study focuses on the stability of γ-irradiated polymers used in single-use plastic bags made of multilayer films for the biopharmaceutical and biotechnological industries. The samples are irradiated at several γ-doses, up to 270 kGy, and compared with a non-irradiated sample used as reference. It shows that the γ-dose, the natural ageing up to six months and the γ-dose Ã ageing interaction are the most influential factors.
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Journal: Analytica Chimica Acta - Volume 981, 15 August 2017, Pages 11-23