کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5131050 1490862 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discriminative sensing of DOPA enantiomers by cyclodextrin anchored graphene nanohybrids
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Discriminative sensing of DOPA enantiomers by cyclodextrin anchored graphene nanohybrids
چکیده انگلیسی


- Discriminative sensing of DOPA enantiomers was investigated.
- Cyclodextrin (x-CD/rGO, x: α-, β-, γ-) anchored graphene nanohybrids were employed.
- The electrochemical measurements and molecular docking studies were performed.
- The results showed that γ-CD/rGO was the most convenient nanohybrid.

Discriminative sensing of chiral species with a convenient and robust system is a challenge in chemistry, pharmaceutics and particularly in biomedical science. Advanced nanohybrid materials for discrimination of these biologically active molecules can be developed by combination of individual obvious advantages of different molecular scaffolds. Herein, we report on the comparison of the performance of cyclodextrin functionalized graphene derivatives (x-CD/rGO, x: α-, β-, γ-) for discrimination of DOPA enantiomers. Within this respect, electrochemical measurements were conducted and the experimental results were compared to molecular docking method. Thanks to cavity size of γ-CD and the unique properties of graphene, rGO/γ-CD nanohybrid is capable of selective recognition of DOPA enantiomers. Limit of detection (LOD) value and sensitivity were determined as 15.9 μM and 0.2525 μA μM−1 for D-DOPA, and 14.9 μM and 0.6894 μA μM−1 for L-DOPA.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 970, 1 June 2017, Pages 30-37
نویسندگان
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