Application of MoS2 modified screen-printed electrodes for highly sensitive detection of bovine serum albumin

- MoS2 nanoflakes have been used for an electrochemical immunosensor.
- The sensor's response was proportional to the antigen concentration.
- Highly sensitive and specific detection of iron-binding protein 'BSA' is achieved.
- A wide linear range of detection of BSA is demonstrated.

The present work reports the application of a new molybdenum disulphide (MoS2)-based electrochemical platform for highly sensitive quantitation of an iron-binding protein, bovine serum albumin (BSA). The gold screen-printed electrodes were modified with MoS2 nanoflakes, followed by bioconjugation with anti-BSA antibodies. Using the above bioelectrode, cyclic voltammetric analysis was carried out in the presence of a Fe3+/Fe2+ redox probe which exhibited a linear response of peak current with varying concentrations of BSA up to 10 ng/mL (with a detection limit of 0.006 ng/mL). This study is novel in that it shows a considerable enhancement of signal during electrochemical sensing of a protein.

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