Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl] benzamide derivatives

In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterized by elemental analyses, UV–Visible, FT–IR, 1H & 13C NMR spectroscopic techniques. The molecular structures of 1–3 were determined by single crystal X-ray crystallography which shows twists of up to 70° about the (S)C–NC(O) bonds. All the synthesized compounds show good antioxidant property and cytotoxic potential against Ehrlich Ascites Carcinoma (EAC) cancer cell line.

Acylthiourea derivatives were prepared and characterized by analytical and spectral methods. Three dimensional structures of all three compounds were derived by single crystal X-ray crystallography. The acylthiourea derivatives were subjected to in vitro antioxidant and cytotoxicity studies and all the synthesized compounds show good anti-oxidant and cytotoxic potential.Figure optionsDownload high-quality image (134 K)Download as PowerPoint slide