A novel modeling method to evaluate the bioactive contributions of compositions in traditional Chinese medicine

A new modeling method to evaluate multiple compositions' bioactive contribution against the whole traditional Chinese medicine (TCM) extracts was presented and a real sample experiment was carried out for demonstration. The quantitates and antioxidant effects of different DanShen extracts and 13 chemical components were evaluated and evolved in the model by curve fitting and least square optimization. From the model, each component's bioactivity was predicted and the individual contribution over the whole antioxidant activity was calculated also. These data will provide valuable guides for finding new potential bioactive component in TCM.