کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5132893 1492061 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flavanol plasma bioavailability is affected by metabolic syndrome in rats
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Flavanol plasma bioavailability is affected by metabolic syndrome in rats
چکیده انگلیسی


- Maximum flavanol plasma bioavailability is delayed in rats with metabolic syndrome.
- This disease increases first-pass absorption and phase-II metabolism of monomers.
- Flavanol microbial metabolism is disrupted in rat whit metabolic syndrome.

Flavanols, which exert several health benefits, are metabolized after ingestion. Factors such as the host physiological condition could affect the metabolism and bioavailability of flavanols, influencing their bioactivities. This study aimed to qualitatively evaluate whether a pathological state influenced flavanol plasma bioavailability. Standard and cafeteria (CAF) diet fed rats, a robust model of metabolic syndrome (MeS), were administered 1000 mg/kg of flavanol enriched grape seed polyphenol extract (GSPE). Flavanols and their metabolites were quantified by HPLC-MS/MS in plasma before and at 2, 4, 7, 24, and 48 h after GSPE ingestion. Results showed that in CAF administered rats the maximum time of plasma flavanol concentration was delayed and these animals presented higher levels of plasma phase-II metabolites as well as altered microbial metabolites. In conclusion, this study demonstrated that MeS pathological state modified flavanol bioavailability, supporting the hypothesis that flavanol metabolism, and therefore flavanol functionality, depend on the organism's state of health.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 231, 15 September 2017, Pages 287-294
نویسندگان
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