کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5135183 1493427 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overcoming “speed limits” in high throughput chromatographic analysis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Overcoming “speed limits” in high throughput chromatographic analysis
چکیده انگلیسی


- Increase of throughput in chromatographic analysis by high speed autosampler technology.
- Combination with ultrafast chromatographic separation enables analysis of 96 well plates in 17 min.
- Demonstrated for high speed enantiopurity analysis as well as rapid analysis for biocatalyst screening.

The combination of high speed autosampler technology and ultrafast chromatographic separations enables faster high throughput analysis. With an injection cycle time of 10.6 s, MISER (Multiple Injection in a Single Experimental Run) HPLC-MS analysis of a 96 well microplate can be completed in only 17 min. As chromatographic separations in the sub 5 s range become increasingly common, even faster autosamplers will be needed to realize further speed improvements in high throughput LC-MS analysis. Indeed with proper hardware sampling approaches, chromatographic analysis of microplates could approach speeds of spectrophotometric plate readers while maintaining the advantage of multicomponent detection and monitoring.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1499, 26 May 2017, Pages 211-216
نویسندگان
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