کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5135853 | 1493446 | 2017 | 6 صفحه PDF | دانلود رایگان |
- Simple and selective method for the quantitative analysis of C1-C6 amines.
- Simultaneous separation of more than 20 short chain amines by HILIC-ESI-MS/MS.
- Four stable isotope labeled internal standards used for signal normalization.
- Method validation is presented.
A new liquid chromatography-electrospray ionization-tandem Mass Spectrometry (LC-ESI-MS/MS) method was developed for the determination of more than 20 C1-C6 alkyl and alkanolamines in aqueous matrices. The method employs Hydrophilic Interaction Liquid Chromatography Multiple Reaction Monitoring (HILIC-MRM) with a ZIC-pHILIC column and four stable isotope labeled amines as internal standards for signal normalization and quantification of the amines. The method was validated using a refinery process water sample that was obtained from a cooling cycle of crude oil distillation. The averaged within run precision, between run precision and accuracy were generally within 2-10%, 1-9% and 80-120%, respectively, depending on the analyte and concentration level. Selected aqueous process samples were analyzed with the method.
Journal: Journal of Chromatography A - Volume 1480, 13 January 2017, Pages 106-111