کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5136338 1494007 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic lipid profile of hyperlipidemia mice
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Dynamic lipid profile of hyperlipidemia mice
چکیده انگلیسی


- Hyperlipidemia mice had higher levels of ALT, GLC, TG and CHO.
- Hyperlipidemia mice had higher levels of C18:1 and lower C16:1 and C22:6.
- Hyperlipidemia mice had higher monounsaturated unsaturated degrees and lower polyunsaturated ones.

Biomarkers of serum fatty acids in hyperlipidemia need to be elucidated. 90 SPF KM male mice were randomly divided into 18 groups (n = 5/group), control groups, and high fat diet (HFD) groups at 9 time points. On day 7, 10, 15, 18, 21, 24, 28, 31, and 35, the mice were sacrificed; blood was collected into tubes from the eyes, serum samples for clinical biochemistry assays and gas chromatography-mass spectroscopy were attained after centrifugation, and the contents of serum fatty acids were detected with GC-MS. Sections of livers were taken and stored in formalin solution for histological assessments. No species differences existed in all these groups. The contents of C16:1, C18:1, C22:6 were significantly different between HFD groups and the corresponding controls; meanwhile, the proportion of fatty acids, especially the monounsaturated degree, the polyunsaturated degree, changed significantly and regularly (P < 0.05). Thus the three unsaturated fatty acids C16:1, C18:1, C22:6 and the monounsaturated/polyunsaturated unsaturated degrees may be as potential biomarkers of hyperlipidemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volumes 1055–1056, 15 June 2017, Pages 165-171
نویسندگان
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