کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5137048 1494528 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studies on the unique properties of resistant starch and chito-oligosaccharide complexes for reducing high-fat diet-induced obesity and dyslipidemia in rats
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Studies on the unique properties of resistant starch and chito-oligosaccharide complexes for reducing high-fat diet-induced obesity and dyslipidemia in rats
چکیده انگلیسی


- CO-RS attenuated obesity and improved antioxidant status in HF diet fed rats.
- PPAR signaling pathway was significantly enriched after CO-RS intervention.
- Lipogenesis-associated gene expression reduced in CO-RS than either RS or CO.
- CO-RS is potential ingredient for attenuation of impaired lipid metabolism in HF diet.

Anti-obesity effect of chito-oligosaccharides (CO), resistant starch (RS) and their complexes (CO-RS) was investigated using high-fat fed rats. All of three intervention groups showed anti-obesity effect in the following order: CO-RS > CO > RS. This study revealed CO-RS administration achieved the lightest body weight, the lowest liver weight/index and the highest level of total antioxidant capacity in serum. The RNA sequencing data indicated that peroxisome proliferator-activated receptor (PPAR) pathway was significantly enriched by CO-RS administration. Among the genes involved in PPAR pathway, changes in the expression of Cyp7a1 gene were noticed, indicating an accelerated conversion of cholesterol into bile acids. Furthermore, the current study also revealed that, compared to the high-fat diet control, intervention with CO-RS led to significant reduction in mRNA expression of insulin-induced genes (Insig-1), which did not occur in other two interventions, suggesting a different regulatory pathway affecting lipids metabolism compared with either CO or RS.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 38, Part A, November 2017, Pages 20-27
نویسندگان
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