کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137267 | 1494531 | 2017 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A pea (Pisum sativum L.) seed albumin extract prevents colonic DSS induced dysbiosis in mice
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
This study investigates the effects of a pea (Pisum sativum) seed albumin extract (PSE) on the colonic microbiota in a model of experimental dextran sodium sulfate (DSS)-induced colitis in mice. Male C57BL/6J mice were assigned to three groups: one non-colitic and two colitic. Colitis was induced by incorporating DSS (3.5%) in the drinking water for four days, after which DSS was removed. The pre-treated group received orally PSE (15 g/kg·day) starting two weeks before colitis induction, and was maintained for nine days after. Mice pre-treated with PSE showed a recovery in colon length compared with non-treated DSS group. Both RT-qPCR and pyrosequencing analysis showed that DSS induced significant modifications in the microbiota composition of colonic contents and tissue. In conclusion, PSE modulated colonic microbiota in a model of experimental dextran sodium sulfate (DSS)-induced colitis in mice, and prevented colonic DSS induced dysbiosis in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 279-294
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 279-294
نویسندگان
Isabel Aranda-Olmedo, Raquel Ruiz, M. Jesús Peinado, Luis A. Rubio,