کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137299 | 1494531 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Encapsulation in chitosan-based polyelectrolyte complexes enhances antidiabetic activity of curcumin
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Encapsulation in chitosan-based polyelectrolyte complexes enhances antidiabetic activity of curcumin Encapsulation in chitosan-based polyelectrolyte complexes enhances antidiabetic activity of curcumin](/preview/png/5137299.png)
چکیده انگلیسی
Low bioavailability, poor aqueous stability and lack of appropriate delivery systems delimit the chemotherapeutic effect of curcumin. In this study, curcumin was encapsulated in chitosan-based polyelectrolyte complexes and its antidiabetic activities were assessed using in vitro α-amylase inhibitory assay and in vivo antihyperglycaemic effect in alloxan-induced rats. Microscopic examination showed nanoformulations (<50 nm) of curcumin loaded in chitosan-alginate complex. Improved encapsulation efficiency (64-76%), loading capacity (20-26%) and yield (50-72%) were achieved. Complexation of chitosan with alginate reduced loss of curcumin by 20% and extended mean release time by 40 min in simulated gastric fluid. Time dependent study showed that the α-amylase inhibitory activity of curcumin was enhanced via nanoencapsulation. Oral administration of sub-therapeutic dosage of curcumin (50 mg/kg b.wt.) nanoencapsulated in chitosan-based complexes caused significant reduction in hyperglycaemia within 7 days of treatment. Overall, chemotherapeutic effectiveness of curcumin was enhanced via nanoencapsulation in chitosan-based polyelectrolyte complexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 584-594
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 584-594
نویسندگان
Jubril Olayinka Akolade, Hussein Oyelola B. Oloyede, Paul Chidozie Onyenekwe,