کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137303 | 1494531 | 2017 | 7 صفحه PDF | دانلود رایگان |
- Dietary enterolignans were studied in wild-type and Abcg2â/â female mice.
- The role of ABCG2 in the in vitro transport of enterodiol was demonstrated.
- ABCG2 was involved in plasma disposition of enterolignans.
- Transport of enterolignans into milk was ABCG2-dependent.
- Enterolignans and glucuronide metabolites were accumulated in mammary gland.
Lignans are phytoestrogens widely used in dietary supplements and functional foods. After oral ingestion, these polyphenols are metabolized to enterolignans, the main gut microbiota-derived metabolites with weak estrogenic/anti-estrogenic activities. The ABCG2 transporter is highly expressed in the mammary gland and could be responsible for enterolignan accumulation. We aimed here at evaluating the levels of enterolignans and their conjugates in plasma, milk and mammary tissue from wild-type and knockout Abcg2â/â female mice after a lignan-enriched diet for one week. In vitro transepithelial transport of enterolignans was also assayed with ABCG2-transduced cells. Enterolactone and enterodiol levels were higher in plasma and lower in milk from Abcg2â/â compared with wild-type mice. Both enterolactone and enterodiol were accumulated in the mammary gland but with significant differences only for enterolactone. Our results suggest that ABCG2 may be determinant for plasma and milk levels of enterolignans whose accumulation could exert chemopreventive effects against breast cancer.
Journal: Journal of Functional Foods - Volume 35, August 2017, Pages 648-654