کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137387 | 1494529 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Yacon flour (Smallanthus sonchifolius) attenuates intestinal morbidity in rats with colon cancer
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Yacon flour (YF) (Smallanthus sonchifolius) is source of fructooligosaccharides (FOS) which are prebiotic with effects unknown in the colorectal cancer (CRC). This study investigated the intestinal effects of supplementation with 7.5% FOS from YF for 8 weeks on CRC induced by 1.2-dimethylhydrazine (25 mg/kg/body weight) in male Wistar rats. The animals were divided in groups: S (without YF and without induced CRC, n = 10), Y (with YF and without induced CRC, n = 10), C (without YF and with induced CRC, n = 10) and CY (with YF and with induced CRC, n = 10). The animals that received YF had a percentage reduction of aberrant crypts focus in more than 40%, lower intestinal permeability, luminal content more acidic and with higher concentrations of SCFA. In addition, there was an increase in the depth and number of colonic crypts. In conclusion, we observed that YF promoted beneficial effects on the intestinal health of animals with induced CRC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 37, October 2017, Pages 666-675
Journal: Journal of Functional Foods - Volume 37, October 2017, Pages 666-675
نویسندگان
Mariana Grancieri, Neuza Maria Brunoro Costa, Maria das Graças Vaz Tostes, Daniela Silva de Oliveira, Louisiane de Carvalho Nunes, LetÃcia de Nadai Marcon, ThaÃsa Agrizzi Veridiano, Mirelle Lomar Viana,