Bacupari peel extracts (Garcinia brasiliensis) reduce high-fat diet-induced obesity in rats

- Bacupari may be used as a potential therapeutic agent for managing obesity.
- Garcinia brasiliensis presented potent anti-obesity activities.
- Bacupari extract regulated lipogenic genes such as FAS, PPAR-γ, and LPL.

The aim of this study was to determine the effect of ethanol extract of bacupari peel (EEB) on the adiposity and inflammation modulation in obese Wistar rats. The group treated with high fat diet plus EEB (BHFD) presented weight gain, visceral fat, and lee, and an adiposity index similar to the negative control group (AIN-93M). Also, the BHFD group showed antioxidant and anti-inflammatory effect, increase of peroxisome proliferator activated receptor-γ (PPAR-γ) and Interleukin-10 (IL-10) expression, and decreasing expression of lipoprotein lipase (LPL) and fatty acid synthase (FAS), and reduced the tumor necrosis factor-α (TNF-α), blood levels of glucose, alanine aminotransferase, and adipocyte hypertrophy. The molecular docking showed that morelloflavone and 7-epiclusianone compounds from bacupari extract interacted with PPAR-γ receptor, hydrophobic interaction, indicating an agonist activity of these compounds. Thus, we demonstrated that extract of bacupari presented anti-obesity activities.