کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137410 | 1494537 | 2017 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness](/preview/png/5137410.png)
- CurQfen®, a novel curcumin compound, reduces brachial pulse pressure in obese men.
- Aortic stiffness was reduced by CurQfen® in subjects with increased baseline values.
- Interleukin-13 is inversely related to aortic stiffness in CurQfen® responders.
Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen®, would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI ⩾ 30.0 kg/m2) were randomized into placebo (n = 11, BMI = 33.18 ± 3.38 kg/m2) and curcumin (n = 11, BMI = 33.29 ± 3.69 kg/m2) supplemented groups. When CurQfen® was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 ± 0.83 m/s v. 5.84 ± 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness.
Journal: Journal of Functional Foods - Volume 29, February 2017, Pages 154-160