کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137476 | 1494539 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antiproliferative effects of α-tomatine are associated with different cell death modalities in human colon cancer cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Antitumour effects of α-tomatine were studied during 24 hours in a panel of human colon cancer cells. α-Tomatine proved to induce dose-dependent cytotoxicity resulting in morphologically varying cell demise with predominantly occurring necrotic phenotypes and minor presence of cells dying via caspase-independent apoptosis. Analyses into the nature of mechanisms responsible for activation of cell death revealed that following α-tomatine treatment, changes in RIP3 and RIP1 protein expression take place along with cyclophilin D mitochondrial accumulation. Moreover, in treated cells, lysosomal membrane permeabilization as well as mitochondrial perturbation with subsequent mitochondrial release of apoptosis-inducing factor (AIF) contributes to the execution of diverse death phenotypes possibly via enhanced activity JNK but in the absence of significant oxidative stress. Thus α-tomatine exhibits significant antitumour activity in colon cancer cells via targeting their membranous compartments and inducing both necroptosis and apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 27, December 2016, Pages 491-502
Journal: Journal of Functional Foods - Volume 27, December 2016, Pages 491-502
نویسندگان
Kamil Rudolf, Emil Rudolf,