کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137488 | 1494539 | 2016 | 7 صفحه PDF | دانلود رایگان |
- Thermolysin and pepsin hydrolysate of egg white (EWH) significantly reduced blood pressure in spontaneously hypertensive rats.
- (EWH) enhanced vascular relaxation and nitric oxide bioavailability, and modified angiotensin II receptor expression.
- These anti-hypertensive effects appear to be independent of ACE inhibition.
Angiotensin converting enzyme (ACE) inhibitory peptides from egg have demonstrated reduction of blood pressure (BP) in vivo. In this study we evaluated the effects of egg white hydrolysate (EWH) prepared by thermolysin and pepsin in spontaneously hypertensive rats (SHRs). Fourteen to sixteen week old SHRs were implanted with telemetry devices. After recovery, the rats were divided randomly into three groups: untreated, EWH low dose (250âmg/kg BW), and EWH high dose (1000âmg/kg BW) for 12 days. BP showed a significant reduction in the EWH high dose group compared to untreated controls. BP reduction was associated with enhanced ex vivo vasodilation reduced oxidative/nitrosative stress, reduced angiotensin converting enzyme and angiotensin II type 1 receptor expression, while enhanced angiotensin II type 2 receptor expression. Circulating level of angiotensin II was unaffected. Thus, EWH exerted anti-hypertensive effects in SHRs through multiple mechanisms of vascular relaxation and RAS modulation.
Journal: Journal of Functional Foods - Volume 27, December 2016, Pages 667-673