کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137527 | 1494538 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The ameliorative effects of probiotic Lactobacillus fermentum strain RS-2 on alloxan induced diabetic rats
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
This study intended to evaluate the probiotic potential of Lactobacillus fermentum RS-2 by in-vitro and in-vivo methods. Alloxan was injected intraperitoneally and animals were euthanised on 60th day post-challenge. The ameliorative effect of strain RS-2 alone and compare with standard strain ME-3, on glucose level, lipid parameters was performed. Oxidative stress was determined on the basis of enzyme markers. RS-2 strain showed a better survivability (55.60 ± 24%) in comparison with ME-3 (21.36 ± 27%) at pH 2.0 after 3 h and found potent antagonist against robust pathogens as compared to ME-3. The antioxidative activity of RS-2 cell lysate as% inhibition of linoleic acid peroxidation and % superoxide anion scavenging effect was observed to be 51.68 ± 0.32 and 43.5 ± 0.67%, respectively. Feeding rats with fermented milk containing RS-2 was found to significantly delay the severity of diabetes by amelioration of fasting blood glucose, and antioxidative stress markers in liver and blood as compared to diabetic control group.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 28, January 2017, Pages 275-284
Journal: Journal of Functional Foods - Volume 28, January 2017, Pages 275-284
نویسندگان
Narendra Kumar, Sudhir Kumar Tomar, Kiran Thakur, Ashish Kumar Singh,