کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137661 | 1494535 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lactobacillus reuteri induces intestinal immune tolerance against food allergy in mice
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
The effect of Lactobacillus reuteri against food allergy was investigated in ovalbumin (OVA)-sensitized BALB/c mice. Oral administration with L. reuteri restored the deteriorated profile of enteric flora, and attenuated allergic diarrhoea, mast cell activation, and serum IgE production in allergic mice. The production of signature T helper (Th)1 and 2 cytokines, namely IFN-γ and IL-4, by splenocytes was suppressed by L. reuteri. Concordantly, the intestinal expression of IFN-γ, IL-4, T-bet and GATA3 was down-regulated. However, L. reuteri augmented the expression of IL-10, TGF-β and Foxp3, and the number of IL-10-secreting CD11c+CD103+ mesenteric lymph node (MLN) cells. Furthermore, direct exposure to heat-killed L. reuteri attenuated OVA-induced cell proliferation and IL-2 secretion by MLN cells. These results demonstrate that L. reuteri possesses anti-allergic activities via modulating enteric flora and promoting tolerogenic immune responses, and suggest L. reuteri as a functional probiotic against food allergy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 31, April 2017, Pages 44-51
Journal: Journal of Functional Foods - Volume 31, April 2017, Pages 44-51
نویسندگان
Chung-Hsiung Huang, Yu-Chin Lin, Tong-Rong Jan,