High-sensitive bioorthogonal SERS tag for live cancer cell imaging by self-assembling core-satellites structure gold-silver nanocomposite

A new SERS tag with core-shell structure based on gold nanoparticles core containing alkynyl molecule and silver nanoparticle satellites shell, was designed and synthesized for live cancer cells Surface enhanced Raman scattering (SERS) imaging in Raman-silence region. The tag shows 10-fold increase in the Raman signals intensity.184