Coupling shell-isolated nanoparticle enhanced Raman spectroscopy with paper chromatography for multi-components on-site analysis

By coupling shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) with paper chromatography, a facile method was developed for simultaneous on-site separation and optical detection of multiple components. The established method features high sensitivity of plasmon-enhanced sensing strategies and sufficient temporal and spatial resolution of planar chromatographic techniques.125