Overview of experimental and computational methods for the determination of the pKa values of 5-fluorouracil, cyclophosphamide, ifosfamide, imatinib and methotrexate

IMT pKa1 2.5, pKa2 4.0, pKa3 8.3 [IMT-H3L3+/IMT-H2L2+/IMT-HL+/MTX-L].