Synthesis and antitumor activity of some new pyrazolo[1,5-a]pyrimidines

A new series of pyrazolo[1,5-a]pyrimidine derivatives 7a-i, 11a-c and their relevant Schiff bases 13a-c were synthesized. All the newly synthesized compounds were screened for their in vitro antitumor activity against three human carcinoma cell lines, namely colorectal carcinoma (HCT116), prostate adenocarcinoma (PC-3) and liver carcinoma (HepG-2) using MTT cytotoxicity assay at 100 μg/mL.