DNA binding, cleavage and cytotoxicity of a novel dimetallic Fe(III) triaza-cyclononane complex

The bimetallic Fe(III) complex of 2,6-bis(1,4,7-triazacyclonon-1-ylmethyl)-4-methylphenol relaxes supercoiled pUC19 DNA into the nicked form at low micromolar concentration in the presence of an external reducing agent and exhibits significant cytotoxic effects against colon LoVo cancer cells with an IC50 value 2.5 times lower than that of cisplatin.64