Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity against Trypanosoma cruzi

Coordination of the fac-Re(CO)3 moiety to bioactive thiosemicarbazones HL led to fac-[Re(CO)3Br(HL)] compounds with high activities on bloodstream Trypanosoma cruzi and good selectivities towards the parasite. Complexes convert into [Re2(CO)6(L)2] in solution and inhibit parasite mitochondrial respiration, effect shown by decrease of oxygen consumption rate, without generating radical oxygen species.88