New imidoyl-indazole platinum (II) complexes as potential anticancer agents: Synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies

Six new Pt(II)-based complexes were synthesized and characterized. Cytotoxicity evaluation and cell death in vitro was performed in four cancer cell lines and VERO cells as control. In addition, experimental and theoretical DNA binding assays were achieved. Overall, induction of cell death by dependent and independent DNA-Pt(II) interactions were possible.263