A metal-organic framework based PCR-free biosensor for the detection of gastric cancer associated microRNAs

Five sensing platforms were formed from MOF 1, respectively with five carboxyfluorescein labeled ss-DNA. These sensing platforms can be used for the detection of five type miRNAs, which are expressed abnormally in the plasma of gastric carcinoma patients. Each sensing system is effective and reliable for the detection of its complementary target miRNA with the detection limits from 91 to 559 pM, and is not interfered by the other four miRNA sequences.331