Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes

Mechanisms underlying the anti-tumor effect of two [Ru(III)-bis(aminophenolate)] complexes are investigated. A novel fully quantitative approach to DNA-[complex] binding is applied and quantitatively validated with time-resolved fluorescence spectroscopy. These complexes induce different programmed cell death routes and exert a different effect on the cell cycle despite their structural resemblance.165