Biochemical characterization of the bacterial peroxidase from the human pathogen Neisseria gonorrhoeae

Neisseria gonorrhoeae bacterial peroxidase was heterologously produced in higher yield than previously reported, enabling its biochemical characterization. Specific activity is dependent on reductive activation and calcium, which also modulates redox properties and monomer-dimer equilibrium. This enzyme is highly specific and a first line defense mechanism against exogenously produced hydrogen peroxide.101