کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5156606 1500583 2017 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bio-responsive alginate-keratin composite nanogels with enhanced drug loading efficiency for cancer therapy
ترجمه فارسی عنوان
نانولوله های کامپوزیت آلژینات و کراتین بی حس کننده با افزایش راندمان بارگیری مواد مخدر برای درمان سرطان
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
This article presents a novel dual-stimuli responsive nanogel prepared from human hair keratin and alginate through simple crosslinking method. Keratin offer the crosslinking structure and bio-responsive ability and alginate ameliorated properties of nanogels including particle size, stability and drug loading capacity. The resultant keratin-alginate nanogels (KSA-NGs) could function as promising vectors for doxorubicin hydrochloride (DOX) with a super-high drug-loading rate of 52.9% (w/w) and dual-stimuli responsive behavior to GSH and trypsin. Cellular uptake results indicated DOX loaded KSA-NGs (DOX@KSA-NGs) are efficiently internalized in 4T1 and B16 cells in vitro, with a fast DOX release into cells under intracellular GSH and trypsin levels. In vitro cytotoxicity results further manifested that DOX@KSA-NGs behaved equivalent inhibition effects on tumor cells to DOX. In vivo experiments showed that DOX@KSA-NGs had a better anti-tumor effect and lower side effects compared to free drugs. These bio-responsive KSA-NGs have potential applications as nanocarriers for cancer therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 175, 1 November 2017, Pages 159-169
نویسندگان
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