کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5156649 | 1500583 | 2017 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polysaccharides from brown algae Sargassum duplicatum: the structure and anticancer activity in vitro
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The laminaran SdL and fucoidan SdF were isolated from brown algae Sargassum duplicatum. SdL was 1,3;1,6-β-d-glucan (1,3:1,6 = 6:1) with a main chain, represented by 1,3-linked glucose residues, due to NMR spectroscopy data. Single glucose residues could form branches at C6. Unusual structure of fucoidan SdF was studied by chemical and enzymatic methods, NMR spectroscopy of desulfated and deacetylated polysaccharide and mass spectrometry of fucoidan fragments labeled with 18O. Fucoidan was sulfated (31.7%) and acetylated galactofucan (Fuc:Gal â¼Â 1:1) with a main chain of 1,4-linked alternating α-l-fucose and β-d-galactose residues. Side chains were represented by extensive (DP â¥Â 5) 1,3-linked 2,4-disulfated α-l-fucose residues with branching points at C2. Fucose residues in the main chain were sulfated at C2 and less at C3, while galactose residues were sulfated at C2, C3, and less at C4, C6. The fucoidan SdF was effective against colony formation of colon cancer cells in vitro.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 175, 1 November 2017, Pages 547-556
Journal: Carbohydrate Polymers - Volume 175, 1 November 2017, Pages 547-556
نویسندگان
Roza V. Usoltseva, Stanislav D. Anastyuk, Natalia M. Shevchenko, Valerii V. Surits, Artem S. Silchenko, Vladimir V. Isakov, Tatiana N. Zvyagintseva, Pham Duc Thinh, Svetlana P. Ermakova,