کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5156654 | 1500583 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of a water-soluble chitosan derivative and its potential for submucosal injection in endoscopic techniques
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کلمات کلیدی
EMRESDPCA - PCAalcian blue - آبی آبیperiodic acid-Schiff - اسید فسفریک SchiffUltraviolet - اشعه فرابنفشEMR, endoscopic mucosal resection - برداشتن مخاط آندوسکوپیSubmucosal injection - تزریق سابوکالسendoscopic submucosal dissection - تشخیص آندوسکوپی ساب موکوسیالFibrinogen - فیبرینوژنPAS - نهChitosan - کیتوسان Sulfate group - گروه سولفات
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization of a water-soluble chitosan derivative and its potential for submucosal injection in endoscopic techniques Characterization of a water-soluble chitosan derivative and its potential for submucosal injection in endoscopic techniques](/preview/png/5156654.png)
چکیده انگلیسی
To examine the potential of chitosan-based agents for submucosal injection in endoscopic techniques, a chitosan derivative was prepared with lactose moieties linked to the amino groups of its glucosamine units (CH-LA). After dissolving CH-LA in neutral pH solutions, including physiological saline (CH-LA-S), its response to different concentrations of anionic glycosaminoglycans and proteins in the surrounding environment was examined. The CH-LA-S form changed in the presence of sulfated glycosaminoglycans (heparin, chondroitin sulfate, and mucin) and protein (fibrinogen). High concentrations of sulfated substrates in the solution caused the formation of larger structures. In contrast, in the presence of hyaluronan, 30Â mg/mL CH-LA-S did not form any large structures. Submucosal injection of 30Â mg/mL CH-LA-S into extracted swine stomachs showed a strong lifting effect of the gastric mucosa. These results indicate the potential utility of CH-LA-S as a submucosal injection for endoscopic techniques such as endoscopic submucosal dissection and mucosal resection of tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 175, 1 November 2017, Pages 592-600
Journal: Carbohydrate Polymers - Volume 175, 1 November 2017, Pages 592-600
نویسندگان
Hidemi Hattori, Hironori Tsujimoto, Kazuo Hase, Masayuki Ishihara,