کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5156801 | 1500584 | 2017 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Construction and characterization of nanosized curdlan sulfate/chitosan polyelectrolyte complex toward drug release of zidovudine
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Construction and characterization of nanosized curdlan sulfate/chitosan polyelectrolyte complex toward drug release of zidovudine Construction and characterization of nanosized curdlan sulfate/chitosan polyelectrolyte complex toward drug release of zidovudine](/preview/png/5156801.png)
چکیده انگلیسی
In this study, as-synthesized curdlan sulfate (CRDS) with a flexible random coil chain was selected as a polyanion to construct nanosized polyelectrolyte complexes (PECs) with a polycation, chitosan (CS), via electrostatic interactions. Nanosized PECs were formed simply by mixing CRDS (0.5Â mg/mL) and CS (0.5Â mg/mL) at a mass ratio of 2:1 at pH 3.5. The CRDS/CS PECs exhibited a spherical morphology with a Z-average diameter of around 180Â nm and a zeta potential value of about â38Â mV. Subsequently, zidovudine (AZT) as a model antiviral drug was successfully encapsulated into the nanosized PECs with a favorable drug loading efficiency. The AZT-loaded PECs presented a controlled and pH-dependent AZT release profile. These findings suggest that the CRDS/CS PECs constructed in the present study can be developed as potential nanocarriers for drug delivery applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 174, 15 October 2017, Pages 209-216
Journal: Carbohydrate Polymers - Volume 174, 15 October 2017, Pages 209-216
نویسندگان
Jing-Kun Yan, Yao-Yao Wang, Wen-Yi Qiu, Jian-Yong Wu,