کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5156857 | 1500584 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
“Click” hyaluronan based nanohydrogels as multifunctionalizable carriers for hydrophobic drugs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: “Click” hyaluronan based nanohydrogels as multifunctionalizable carriers for hydrophobic drugs “Click” hyaluronan based nanohydrogels as multifunctionalizable carriers for hydrophobic drugs](/preview/png/5156857.png)
چکیده انگلیسی
The developed system is proposed for the delivery of hydrophobic drugs; for this purpose, dexamethasone, piroxicam and paclitaxel were used as model drugs; these molecules were loaded into NHs with high efficiency by film-hydration technique. Furthermore, a HA-c-Rfv derivative bearing an excess of propargylic portions was capable to react with other N3-derivatized molecules, opening the route to a wide spectrum of functionalization opportunities: in this direction, PEG-N3 has been tested as a model molecule for the preparation of PEGylated NHs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 174, 15 October 2017, Pages 706-715
Journal: Carbohydrate Polymers - Volume 174, 15 October 2017, Pages 706-715
نویسندگان
Giuliana Manzi, Nicole Zoratto, Silvia Matano, Rocchina Sabia, Claudio Villani, Tommasina Coviello, Pietro Matricardi, Chiara Di Meo,