کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5156860 | 1500584 | 2017 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anticoagulant and antithrombotic effects of chemically sulfated fucogalactan and citrus pectin
ترجمه فارسی عنوان
اثرات ضد انعقادی و آنتی ترومبوتیک فوکوالالکتان شیمیایی و پکتین مرکبات
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Citrus pectin (CP14) from Citrus sinensis, and a fucogalactan (E) and a glucan (G16) from Agaricus bisporus were isolated and structurally characterized. CP14 was constituted by (1â4)-linked α-d-GalpA units, E was composed by a (1â6)-linked α-d-Galp main-chain, partially substituted at O-2 by non-reducing end-units of α-l-Fucp or α-d-Galp, and partially methylated at O-3, whereas G16 was composed of (1â6)-linked β-d-Glcp units. The polysaccharides were sulfated giving rise to CP14S, ESL and G16S. The APTT and PT assays showed a decreasing order of anticoagulant activity for ESL, CP14S and G16S, respectively. ESL and CP14S showed greater anticoagulant activity. However, ESL reduced thrombus formation to 32.3% at a dose of 6.0 mg kgâ1, whereas CP14S inhibited totally the thrombus formation at 3.0 mg kgâ1, in vivo. NMR and methylation analyses showed that α-d-GalAp units of CP14S were sulfated in 2,3-O-position, whereas ESL was mainly sulfated in 2-O-, 2,3-O- and 2,3,4-O-positions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 174, 15 October 2017, Pages 731-739
Journal: Carbohydrate Polymers - Volume 174, 15 October 2017, Pages 731-739
نویسندگان
Yony Román, Helyn P. de Oliveira Barddal, Marcello Iacomini, Guilherme L. Sassaki, Thales R. Cipriani,