کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5156860 1500584 2017 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anticoagulant and antithrombotic effects of chemically sulfated fucogalactan and citrus pectin
ترجمه فارسی عنوان
اثرات ضد انعقادی و آنتی ترومبوتیک فوکوالالکتان شیمیایی و پکتین مرکبات
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Citrus pectin (CP14) from Citrus sinensis, and a fucogalactan (E) and a glucan (G16) from Agaricus bisporus were isolated and structurally characterized. CP14 was constituted by (1→4)-linked α-d-GalpA units, E was composed by a (1→6)-linked α-d-Galp main-chain, partially substituted at O-2 by non-reducing end-units of α-l-Fucp or α-d-Galp, and partially methylated at O-3, whereas G16 was composed of (1→6)-linked β-d-Glcp units. The polysaccharides were sulfated giving rise to CP14S, ESL and G16S. The APTT and PT assays showed a decreasing order of anticoagulant activity for ESL, CP14S and G16S, respectively. ESL and CP14S showed greater anticoagulant activity. However, ESL reduced thrombus formation to 32.3% at a dose of 6.0 mg kg−1, whereas CP14S inhibited totally the thrombus formation at 3.0 mg kg−1, in vivo. NMR and methylation analyses showed that α-d-GalAp units of CP14S were sulfated in 2,3-O-position, whereas ESL was mainly sulfated in 2-O-, 2,3-O- and 2,3,4-O-positions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 174, 15 October 2017, Pages 731-739
نویسندگان
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