کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157045 | 1500595 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs
ترجمه فارسی عنوان
فرمولاسیون میکروارگانیسم های بوم شناختی با پلی ساکارید بذر تامارند جهت بهبود حمل و نقل مواد مخدر از طریق مغز
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Targeted delivery and retention of drug formulations in the olfactory mucosa, the target site for nose-to-brain drug absorption is a major challenge due to the geometrical complexity of the nose and nasal clearance. Recent modelling data indicates that 10 μm-sized microparticles show maximum deposition in the olfactory mucosa. In the present study we tested the hypothesis that 10 μm-sized mucoadhesive microparticles would preferentially deposit on, and increase retention of drug on, the olfactory mucosa in a novel 3D-printed human nasal-replica cast under simulated breathing. The naturally occurring mucoadhesive polymer, tamarind seed polysaccharide (TSP) was used to formulate the microparticles using a spray drying technique. Physicochemical properties of microparticles such as size, morphology and mucoadhesiveness was investigated using a combination of laser diffraction, electron microscopy and texture-analysis. Furthermore, FITC-dextrans (5-40 kDa) were incorporated in TSP-microparticles as model drugs. Size-dependent permeability of the FITC-dextrans was observed ex vivo using porcine nasal mucosa. Using the human nasal-replica cast, greater deposition of 10 μm TSP-microparticles in the olfactory region was observed compared to TSP-microparticles 2 μm in size. Collectively, these findings support our hypothesis that 10 μm-sized mucoadhesive microparticles can achieve selective deposition and retention of drug in the olfactory mucosa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 163, 1 May 2017, Pages 216-226
Journal: Carbohydrate Polymers - Volume 163, 1 May 2017, Pages 216-226
نویسندگان
Sasi B. Yarragudi, Robert Richter, Helen Lee, Greg F. Walker, Andrew N. Clarkson, Haribalan Kumar, Shakila B. Rizwan,