کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157352 | 1500592 | 2017 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of a chitosan-based photo-sensitive hydrogel and its biocompatibility and biodegradability
ترجمه فارسی عنوان
سنتز هیدروژل حساس به حساسیت روی کیتوزان و سازگاری زیستی و تجزیه زیستی آن
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کلمات کلیدی
کیتوزان، عکس حساس، هیدروژل، زیست سازگاری، تجزیه زیستی،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Hydroxyethyl chitosan (HECTS) is one of the most important water soluble derivatives of chitosan. In this study, photo-sensitive azidehydroxyethyl chitosan (AZ-HECTS) was synthesized with grafting degree 3.4%, and its water solution resulted in an insoluble hydrogel by 254Â nm UV irradiation for 90Â s. AZ-HECTS hydrogels, with water absorption 86.21%, had little impact on growth of mouse fibroblast (L929) and presented good cell biocompatibility. Obvious sudden degradation stage, slow degradation stage and no apparent toxicity was observed after AZ-HECTS hydrogels implanted into rats, and tissue inflammation was slighter, which indicated favorable biological safety. Furthermore, AZ-HECTS hydrogels was loaded with heparin, and released 50% of heparin accumulated 14Â d. AZ-HECTS-heparin hydrogels showed inhibitory effects on L929, and pro-growth functions within vascular endothelial cells seeded on the hydrogels, meanwhile a positive influence on vascular endothelial growth factor expression. In conclusion, AZ-HECTS hydrogels possessed favorable biocompatibility and biodegradability and had good potential as drug carrier.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 166, 15 June 2017, Pages 228-235
Journal: Carbohydrate Polymers - Volume 166, 15 June 2017, Pages 228-235
نویسندگان
Ming He, Baoqin Han, Zhiwen Jiang, Yan Yang, Yanfei Peng, Wanshun Liu,