کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5157487 1500602 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design of chondroitin sulfate-based polyelectrolyte nanoplexes: Formation of nanocarriers with chitosan and a case study of salmon calcitonin
ترجمه فارسی عنوان
طراحی نانوپلاس های پلی الکترولیتی مبتنی بر سولفات کاندرویتین: تشکیل نانوکاریائین با کیتوزان و مطالعه موردی کلسایتونین سالمون
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
The aim of this work was to examine the formation and properties of chondroitin sulfate (CHON)-based nanoparticles (NPs), namely CHON/chitosan (CHIT), CHON/CHIT/calcitonin (sCT) and CHON/sCT. Both, positively and negatively charged CHON/CHIT NPs have been successfully obtained with properties that were dependent on the polymer mixing ratio, polymer concentration and molecular weight of CHIT. sCT was successfully loaded into CHON/CHIT NPs with efficiency close to 100% and notably high loading (up to 33%). A new type of NPs composed of CHON and sCT (a binary system) has been successfully developed. CHON/sCT NPs offer the advantage of a very high drug loading up to 73%. The particle size of CHON-based NPs increased in PBS, acetate buffer and in HCl solution compared to that in water, but most of them remained in the nano-range even after 24 h. The media and composition of the nanocarriers were found to affect the release of sCT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 156, 20 January 2017, Pages 276-284
نویسندگان
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