کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157887 | 1500601 | 2017 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Co-loading and intestine-specific delivery of multiple antioxidants in pH-responsive microspheres based on TEMPO-oxidized polysaccharides
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کلمات کلیدی
Sodium hypochlorite (PubChem CID: 23665760)TEMPO-oxidationBeta-Carotene (PubChem CID: 5280489) - بتا کاروتن (PubChem CID: 5280489)Oral delivery system - سیستم تحویل دهان و دندانFluorescein isothiocyanate (PubChem CID: 18730) - فلوورسین ایسوتیوسیانات (PubChem CID: 18730)Chitosan (PubChem CID: 71853) - کیتوزان (PubChem CID: 71853)
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, pH-responsive microspheres loaded with multiple antioxidants were developed for intestine-specific delivery and exhibited synergistic activity. They consist of chitosan (CS)-coated microspheres made of TEMPO-oxidized Konjac glucomannan (OKGM) polymers, of which the carboxyl (COOâ) groups are cross-linked via ferric ions (Fe3+), allowing the hydrophobic (β-carotene) and hydrophilic (anthocyanins) antioxidants to be simultaneously incorporated. CLSM images showed successful co-encapsulation of β-carotene and anthocyanins. The in vitro release kinetics of co-loaded CS-OKGM microspheres in simulated GI fluids indicated that the microspheres retain the dual antioxidants in an acidic gastric environment and release them at intestinal pH. Free radical scavenging experiments demonstrated that multiple antioxidants loaded into OKGM system had synergistic activity with enhanced stability against heat. The multi-functional CS-OKGM microspheres showed great potential for multiple antioxidants and intestine-specific delivery with enhanced stability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 157, 10 February 2017, Pages 858-865
Journal: Carbohydrate Polymers - Volume 157, 10 February 2017, Pages 858-865
نویسندگان
Mengxuan Shi, Jie Bai, Liyun Zhao, Xinrui Yu, Jingjing Liang, Ying Liu, Willem Nord, Yuan Li,