Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots

Twenty diterpenoids were isolated from Jatropha curcas cv. nigroviensrugosus, one of them, lathyranlactone is an unusual diterpenoid lactone possessing a 5/13/3 tricyclic skeleton. Two of the previously known diterpenoids showed more potent cytotoxic activity against the SMMC-772, MCF-7 and SW480 human tumor cell lines than the positive control (cisplatin).