Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Ten isoflavones, cudraisoflavones B-K, together with 27 known isoflavones, were isolated from the EtOAc soluble extract of the fruits of Cudrania tricuspidata. Six of these (compounds 7-9 and 11-13) showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.180