Cytotoxic indole alkaloids from the fruits of Melodinus cochinchinensis

Structures and cytotoxic activity of eight indole alkaloids, including three bisindole alkaloids and five monomers, were reported from the fruits of Melodinus cochinchinensis. Compound 1 has a hitherto unknown form of dimeric linkage in aspidosperma-aspidosperma-type bisindole alkaloids, and compounds 2 and 8 showed moderate cytotoxicity against five human cancer cell lines.69