Thiophene acetylenes and furanosesquiterpenes from Xanthopappus subacaulis and their antibacterial activities

Twenty-three compounds (six previously unknown) were identified from Xanthopappus subacaulis. Thiophene acetylenes showed significant antibacterial activity, in which 10,11-threo-xanthopappin D inhibited Bacillus subtilis with MIC of 7.25 μg/mL, 10,11-erythro-xanthopappin D inhibited Escherichia coli, Bacillus cereus, Staphylococcus aureus, and Erwinia carotovora, with MICs of 12.5, 15.5, 7.25, 7.25 μg/mL, respectively.