Cytotoxic diterpenoids from Salvia yunnanensis

Forty-six abietane type diterpenoids possessing nine different fused ring systems were characterized from the roots of Salvia yunnanensis, six of which (salyunnanins A-F, 1-6) were new metabolites with different nor-abietane, homo-abietane, seco-abietane, and normal abietane architectures. Several of the compounds exhibited substantial cytotoxicity with IC50 values of 0.86-10.1 μM.139