Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.

Twenty-one eudesmane and germacrane derivatives isolated from Inula wissmanniana, including rare 4,5-secoeudesman-12,5-olide (1), eudesman-12,5-olide (2), 3,4-secoeudesman-12-oic acid (3), and germacra-4-en-12,6-olides (4-8), exhibit strong NO inhibition in RAW264.7 macrophages and cytotoxicity in HepG2, PC-3, and MGC-803 tumor cells.