2-O-β-d-Glucopyranosyl-carboxyatractyligenin from Coffea L. inhibits adenine nucleotide translocase in isolated mitochondria but is quantitatively degraded during coffee roasting

2-O-β-d-Glucopyranosyl-carboxyatractyligenin isolated from raw coffee beans inhibits ATP-production in isolated mitochondria by blockage of adenine nucleotide translocase. UPLC-ToF-MS quantification revealed high levels of this phytochemical in lyophilized raw coffee extracts but complete degradation during coffee roasting.