Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

► Zucker fa/fa rats were treated with xanthohumol from hops for 6 weeks. ► Xanthohumol lowered fasting plasma glucose in male animals at a dose of 16.9 mg/kg. ► Xanthohumol lowered body weight in male animals at a dose of 16.9 mg/kg. ► Steady-state plasma and liver tissue levels of xanthohumol agree with dose-effect relationships.