Cytotoxic triterpenoid saponins from husks of Aesculus californica (Spach) Nutt.

► Fifteen saponins were isolated from the husks of Aesculus californica. ► These saponins have a glucopyranosyl moiety at C-3. ► These saponins provide evolutionary and taxonomic evidence for Aesculus. ► The saponins showed cytotoxicity against human non-small cell lung tumor (A549).