Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines

► Thirteen jatrophanes were isolated from the latex of Euphorbia dendroides. ► The structures of compounds were elucidated by spectroscopic techniques. ► The P-glycoprotein activities of the representative set of jatrophanes have been assessed. ► SAR of jatrophanes from two plant locations was discussed.